mycobacterium bovis in humans
Community-based cross-sectional survey of latent tuberculosis infection in Afar pastoralists, Ethiopia, using QuantiFERON TB-Gold In-Tube and tuberculin skin test. Baja California (BCA), Mexico, presents high prevalence of TB in both cattle and humans, making it important to investigate the molecular epidemiology of the disease in . Mycobacterium bovis; biochemical testing; genotyping; human TB; systematic review and meta-analysis. Background Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both livestock and humans. Two independent reviewers (HT and SB) performed full-text review and excluded articles based on specific requirements, which are listed in the PRISMA flow chart (Figure 1). All mammalian species,. Consecutively, Nuru and his colleagues reported higher risk of zoonotic TB among farmers, which is supported by Jenkins et al that relatively higher proportions of M. bovis were found in humans who had close contact with the primary hosts (cattle) (Jenkins et al., 2011; Nuru et al., 2017). 2020 Nov 30;14(11):e0008894. Sales Mariana L., Fonseca Jnior Antnio Augusto, Orzil Lvia, Alencar Andrea Padilha, Silva Marcio Roberto, Issa Marina Azevedo, Soares Filho Paulo Martins, Lage Andrey Pereira, Heinemann Marcos Bryan (2014). CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Although these species can be distinguished by routine genotyping, biochemical characterization and drug susceptibility testing, which generally provide results earlier, have been historically used and can increase the index of suspicion for M. bovis. The persistence of M. bovis in cattle internationally and the failure to pasteurize dairy products in many locations means that further infections in humans should be anticipated. Isolates taken from the same patient were considered as separate episodes if six months apart from each other. Jabbar A, Khan J, Ullah A, Rehman H, & Ali I (2015). eCollection 2022. Molecular identification of Mycobacterium bovis and the importance of zoonotic tuberculosis in Mexican patients, The International Journal of Tuberculosis and Lung Disease, Surveillance and risk management during the latter stages of eradication: Experiences from Australia. Biotechnology and Biological Sciences Research Council, Grant/Award Number: BB/L018977/1; Economic & Social Research Council, Grant/Award Number: BB/L018977/1. References to non-CDC sites on the Internet are Broad diversity of Mycobacterium tuberculosis complex strains isolated from humans and cattle in Northern Algeria suggests a zoonotic transmission cycle. In this regard, the average prevalence of M. bovis infection among PTB cases was lower than that from EPTB; with a subtotal ES of 0.013 (0.0070.020) and 0.041 (0.0040.078) respectively. J. et al. Comparison of Three Molecular Assays for Rapid Detection of Rifampin Resistance in Mycobacterium tuberculosis. Initial examination of 181 contacts determined that 39 (22%) had latent infection: 10 (42%) of 24 who had close exposure to either patient, 28 (28%) of 100 who were exposed to one or both patients in church, and one (2%) of 57 exposed to the second patient at a school. The funnel plot (Figure 5) was constructed from study estimates with pseudo 95% confidence limit against standard error of the estimates. An official website of the United States government. The included studies represented twelve countries from four continents. Today, reservoirs of Mycobacterium bovis, the causative agent of tuberculosis in animals, and sometimes humans, exist in a range of countries . Evaluation of Genotype MTBC Assay for Differentiation of Clinical Mycobacterium tuberculosis Complex Isolates. Unable to load your collection due to an error, Unable to load your delegates due to an error, PRISMA flow diagram shows the searching strategy and screening of eligible studies at different levels of the review process, Findings of a meta-analysis generated from the full model showing the prevalence of, Meta-analysis findings of the random model that shows individual study estimates (ES (95% CI)) of genotyping-based studies and subtotal prevalence of. Nevertheless, the highest prevalence was also recorded from studies conducted in Africa (Jenkins et al., 2011; Nuru et al., 2017) (Figure 3). Bovine tuberculosis eradication programs and routine pasteurization of milk products have led to marked declines in M. bovis TB in humans (1), which accounted for 1.6% of U.S. TB cases in 2014 (6), with regional differences (2,68). Then, further subgroup analysis was done from 14 of the genotyping-based studies to estimate individual study findings and subtotal ES (prevalence of M. bovis) based on specific characteristics. As it is described in Table 1a,,b,b, there were two main sources of samples (specimens). Learn what mycobacterium bovis is, what it causes, and more - WebMD Frontiers | Whole Genome Sequencing Links Mycobacterium bovis From Persons from countries where both types of infection are prevalent could be infected by either species. In spite of the above methodological differences, the pooled prevalence (1.4%) of M. bovis aggregated from genotyping-based studies was comparable with estimates previously reported in the global systematic review by Muller et al (Mller et al., 2013). Twenty-four persons had extended close exposure to either patient and were regarded as high-priority contacts (4); among these, 10 (42%) had positive results at initial testing (Table 1). Quantitative meta-analysis using STATA-14 (metaprop command) was performed. Beside methodological differences on species isolation and identification, the proportion of human M. bovis cases reported by primary studies have shown significant variation that could also be due to some underlying conditions. National Tuberculosis Controllers Association; CDC. Because of its complexity with many specific procedures in these studies, they were broadly classified as conventional- and genotyping-based methods and we found that there was great discrepancy on prevalence data reports between the two methods. In late September 2014, both patients isolates were sent to the United States Department of Agriculture National Veterinary Services Laboratories (NVSL) where whole-genome sequencing was performed. Similarly, the highest (76.7%) and lowest (0.42%) prevalence were reported from two African countries, Tunisia (Siala et al., 2017) and Ethiopia, respectively (Firdessa et al., 2013); however, again the study from Tunisia was performed using conventional-based methods while the one from Ethiopia utilized genotyping for strain identification. MMWR and Morbidity and Mortality Weekly Report are service marks of the U.S. Department of Health and Human Services. Bovine tuberculosis (bTB), caused by Mycobacterium bovis (M. bovis), is a serious re-emerging disease in both animals and humans. The causative agent of bovine tuberculosis, Mycobacterium bovis, is also responsible for some cases of tuberculosis in human beings. 2022 Oct;252:110486. doi: 10.1016/j.vetimm.2022.110486. BOVIS. M. tuberculosis is the main causative agent of human TB, and cattle are the primary host of Mycobacterium bovis; due to close interaction between cattle and humans, M. bovis poses a zoonotic risk. Mycobacterium bovis (M. bovis) is another mycobacterium that can cause TB disease in people. Vet Immunol Immunopathol. Molecular strain typing of Mycobacterium tuberculosis complex in Bamako, Mali. Trends of Mycobacterium bovis isolation and first-line anti-tuberculosis drug susceptibility profile: A fifteen-year laboratory-based surveillance. Taye H, Alemu K, Mihret A, Wood JLN, Shkedy Z, Berg S, Aseffa A (2017). However, because of the observed methodological differences and heterogeneity in first full model (Figure 2), which was strongly significant among studies using the conventional identification method, further subgroup analysis and final pooled estimates were generated from genotyping-based studies only. Genotyping of Mycobacterium tuberculosis complex isolated from humans * Tuberculin skin tests and interferon gamma release assays (IGRA) were used for testing U.S.-born and foreign-born contacts, respectively; IGRA was used for all members of the church where the majority of contacts were foreign born. The counts in the four categories of settings are mutually exclusive. In contrast however, three of these studies used Genotype MTBC (Hain Lifescience GmbH, Germany), a tool that has been shown to also differentiate M. bovis from other MTBC species (Richter et al., 2003). However, it has been shown that M. bovis cultivation is enhanced when pyruvate or glycerol is used as an additive to the media (Schaefer, 1952). The only social connection between the two patients was attendance at the same church, and no common dietary exposure was identified. Whole-genome sequencing can be used to identify species and investigate transmission. Epub 2022 Sep 13. Due to lack of a standard assessment tool that is developed for molecular prevalence studies, the quality of included studies was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist used for observational studies reporting prevalence data (Porritt et al., 2014). CDC twenty four seven. We also examined and compared methods used for identification of the causative agent of zoonotic TB. To shift the existing paradigm, there is a need to have updated and credible scientific evidence. We also observed a high variation in reported prevalence among studies conducted in the same country where the methodology differed. Validation of a real-time PCR assay for the molecular identification of Mycobacterium tuberculosis, GROWTH REQUIREMENTS OF DYSGONIC AND EUGONIC STRAINS OF MYCOBACTERIUM TUBERCULOSIS VAR. M. bovis is most commonly found in cattle and other animals such as bison, elk, and deer. Prevalence of zoonotic tuberculosis and associated risk factors in Central Indian populations, Journal of Epidemiology and Global Health. As disease prevalence in cattle decreases these efforts are sometimes impeded by passage of M. bovis from PMC Infectious TB refers either to TB disease of the lungs or throat, which has the potential to cause transmission to other persons, or to the patient who has TB disease. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5415a2.htm. Human tuberculosis caused by Mycobacterium bovis: a retrospective comparison with Mycobacterium tuberculosis in a Mexican tertiary care centre, 20002015. Studies reporting TB prevalence data that were published in English during 10 years from 20 April 2009 to 17 April 2019 were identified through search of PubMed and other sources. Essentially, spoligotyping was the most common procedure. Whereas molecular studies that used to identify and differentiate M. bovis isolates for other purposes such as investigating drug resistance or laboratory-based biomedical research activities were excluded. Most of those studies were conducted in resource-limited countries, however, relied on comparative observational research findings using tuberculin skin tests in both humans and animals, and these procedures could not determine the specific causative agent. Potentially exposed health care workers were notified for follow-up at their respective facilities with a request to report infections to the health department if identified. Individual study estimate (ES), standard error (seES) and the lower and upper confidence intervals were calculated and reported with respect to the relative weight given for each study. Global prevalence of Mycobacterium bovis infections among human The isolate was . Limited disease management and uncontrolled movement of infected cattle are factors contributing to the ongoing transmission of Mycobacterium bovis and that probably increases risk of zoonotic TB (Ameni et al., 2013; Torres-Gonzalez et al., 2013). Torres-Gonzalez P, Cervera-Hernandez ME, Martinez-Gamboa A, Garcia-Garcia L, Cruz-Hervert LP, Bobadilla-del Valle M, Ponce-de Leon A, Sifuentes-Osornio J (2016). Bovine tuberculosis is more prevalent in cattle owned by farmers with active tuberculosis in central Ethiopia. In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias. This review and meta-analysis study has been conducted in accordance with published protocol (ID = CRD42017076409) (Hawult Taye et al., 2017). The chapters are organized for quick access to well-indexed topics, and extensive reference lists are included to aid infectious disease specialists . Wedlich N, Figl J, Liebler-Tenorio EM, Khler H, von Pckler K, Rissmann M, Petow S, Barth SA, Reinhold P, Ulrich R, Grode L, Kaufmann SHE, Menge C. Front Vet Sci. Indeed, genotypic variations of MTBC strains, as well as lack of in-depth knowledge on host-pathogen co-evolutionary relationships, could hide the fundamental information and evidence needed to design effective preventive interventions (Legesse et al., 2011). Meta-analysis was performed on 19 included studies, with a total of 7,185 MTBC isolates identified; 702 (9.7%) of them were characterized as of subspecies M. bovis, but there was a large prevalence difference between the studies, ranging from 0.4% to 76.7%. Each individual study was evaluated based on the above nine JBI measurement criteria and score was given as Yes = 1, No = 0 or Unclear = U. Majoor CJ, Magis-Escurra C, van Ingen J, Boeree MJ, van Soolingen D (2011). The ongoing incidence of M. bovis TB in humans substantiates the need to control bovine tuberculosis globally and to pasteurize all milk and dairy products. The remaining five studies were conducted in four different continents. Human Tuberculosis due toMycobacterium bovisin the United States, 19952005. Five of the studies used phenotyping by biochemical tests as primary identification and differentiation techniques of the mycobacterial isolates (Bobadilla-del Valle et al., 2015; Ghariani et al., 2015; Portillo-Gomez & Sosa-lglesias, 2011; Siala et al., 2017; Torres-Gonzalez et al., 2016). However, over the last three decades, many nucleic acid-based methods have been developed to differentiate strains within the Mycobacterium tuberculosis complex (MTBC), such as restriction fragment length polymorphism (RFLP) analysis, DNA sequencing of target genes and polymorphic DNA analysis (Cousins et al., 1991; Lee et al., 2000; Ramos et al., 2014; Watterson et al., 1998), as well as several PCR-based methods, such as spoligotyping and mycobacterial interspersed repetitive unit-variable number tandem repeats (MIRU-VNTR), which have been extensively used in parallel with commercially available test systems (Bidovec-Stojkovic et al., 2011; Christianson et al., 2010; Mathuria et al., 2008; Shi et al., 2018).
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mycobacterium bovis in humans
